Polynucleotides, or PNs, are one of the most talked-about developments in aesthetic medicine. Derived from DNA, they work in tune with the skin’s own biology, helping restore quality and radiance while keeping results beautifully natural.
In recent years, aesthetic medicine has been moving towards more regenerative approaches. The focus is shifting away from treatments that simply add volume, such as hyaluronic acid fillers, or freeze muscle movement, as with Botox. Increasingly, clients seek procedures that improve skin quality while preserving natural expression. PNs fit neatly within this shift. Rather than adding or blocking, they stimulate the skin’s natural healing processes, encouraging gradual, skin-deep improvement.
PNs are highly purified fragments of DNA, usually sourced from biological material. In cosmetic medicine, they’re used for their biostimulatory action, helping to activate the skin’s natural repair response. Unlike many familiar injectables, they aren’t designed to fill or freeze; instead, they work within the tissue, encouraging regeneration and improving skin quality from the inside out.
Once introduced into the dermis, polynucleotides interact with cells involved in skin renewal. In particular, they stimulate fibroblasts, which are responsible for producing collagen and other structural components. By triggering the skin’s natural repair mechanisms, PNs can help improve elasticity and resilience over time, with a visibly improved texture and tone.
Treatment is carried out using tiny injections, often via mesotherapy-style techniques. It’s a minimally invasive outpatient procedure, usually delivered in several short sessions spaced over time. It tends to be well tolerated, meaning most people can return quickly to normal routines.
Because the approach relies on the skin’s own regenerative response, results are not instant but progressive. Over the following weeks, patients observe improvements in texture, radiance and firmness. The changes are typically subtle and natural, enhancing the complexion without altering features or creating an overdone look.
PNs are particularly suited to skin showing early signs of ageing, as well as dullness, dehydration or a general loss of radiance. Common treatment areas include the face, neck, décolletage and hands. They can be used on their own or alongside other procedures as part of a broader treatment plan, tailored to each client’s needs.
